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dc.contributor.authorRommelse, Nanda N. J.de
dc.contributor.authorFranke, Barbarade
dc.contributor.authorGeurts, Hilde M.de
dc.contributor.authorHartman, Catharina A.de
dc.contributor.authorBuitelaar, Jan K.de
dc.date.accessioned2011-02-11T02:51:00Zde
dc.date.accessioned2012-08-29T23:04:25Z
dc.date.available2012-08-29T23:04:25Z
dc.date.issued2010de
dc.identifier.urihttp://www.ssoar.info/ssoar/handle/document/21591
dc.description.abstractAttention-deficit/ hyperactivity disorder (ADHD) and autism spectrum disorder (ASD) are both highly heritable neurodevelopmental disorders. Evidence indicates both disorders co-occur with a high frequency, in 20–50% of children with ADHD meeting criteria for ASD and in 30-80% of ASD children meeting criteria for ADHD. This review will provide an overview on all available studies [family based, twin, candidate gene, linkage, and genome wide association (GWA) studies] shedding light on the role of shared genetic underpinnings of ADHD and ASD. It is concluded that family and twin studies do provide support for the hypothesis that ADHD and ASD originate from partly similar familial/ genetic factors. Only a few candidate gene studies, linkage studies and GWA studies have specifically addressed this co-occurrence, pinpointing to some promising pleiotropic genes, loci and single nucleotide polymorphisms (SNPs), but the research field is in urgent need for better designed and powered studies to tackle this complex issue. We propose that future studies examining shared familial etiological factors for ADHD and ASD use a family-based design in which the same phenotypic (ADHD and ASD), candidate endophenotypic, and environmental measurements are obtained from all family members. Multivariate multi-level models are probably best suited for the statistical analysis.en
dc.languageende
dc.subject.ddcPsychologyen
dc.subject.ddcPsychologiede
dc.subject.otherAttention-deficit/ hyperactivity disorder; Autism spectrum disorder; Molecular genetics; Shared heritability
dc.titleShared heritability of attention-deficit/ hyperactivity disorder and autism spectrum disorderen
dc.description.reviewbegutachtet (peer reviewed)de
dc.description.reviewpeer revieweden
dc.source.journalEuropean Child & Adolescent Psychiatryde
dc.source.volume19de
dc.publisher.countryDEU
dc.source.issue3de
dc.subject.classozPsychological Disorders, Mental Health Treatment and Preventionen
dc.subject.classozpsychische Störungen, Behandlung und Präventionde
dc.identifier.urnurn:nbn:de:0168-ssoar-215913de
dc.date.modified2011-02-11T10:21:00Zde
dc.rights.licencePEER Licence Agreement (applicable only to documents from PEER project)de
dc.rights.licencePEER Licence Agreement (applicable only to documents from PEER project)en
ssoar.gesis.collectionSOLIS;ADISde
ssoar.contributor.institutionhttp://www.peerproject.eu/de
internal.status3de
dc.type.stockarticlede
dc.type.documentjournal articleen
dc.type.documentZeitschriftenartikelde
dc.rights.copyrightfde
dc.source.pageinfo281-295
internal.identifier.classoz10708
internal.identifier.journal111de
internal.identifier.document32
internal.identifier.ddc150
dc.identifier.doihttps://doi.org/10.1007/s00787-010-0092-xde
dc.description.pubstatusPostprinten
dc.description.pubstatusPostprintde
internal.identifier.licence7
internal.identifier.pubstatus2
internal.identifier.review1
internal.check.abstractlanguageharmonizerCERTAIN
internal.check.languageharmonizerCERTAIN_RETAINED


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