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Genetics of developmental dyslexia
[journal article]
Abstract
Developmental dyslexia is a highly heritable disorder with a prevalence of at least 5% in school-aged children. Linkage studies have identified numerous loci throughout the genome that are likely to harbour candidate dyslexia susceptibility genes. Association studies and the refinement of chromosoma... view more
Developmental dyslexia is a highly heritable disorder with a prevalence of at least 5% in school-aged children. Linkage studies have identified numerous loci throughout the genome that are likely to harbour candidate dyslexia susceptibility genes. Association studies and the refinement of chromosomal translocation break points in individuals with dyslexia have resulted in the discovery of candidate genes at some of these loci. A key function of many of these genes is their involvement in neuronal migration. This complements anatomical abnormalities discovered in dyslexic brains, such as ectopias, that may be the result of irregular neuronal migration.... view less
Classification
General Psychology
Psychological Disorders, Mental Health Treatment and Prevention
Free Keywords
Developmental dyslexia; Genetics; Reading; Spelling
Document language
English
Publication Year
2009
Page/Pages
p. 179-197
Journal
European Child & Adolescent Psychiatry, 19 (2009) 3
DOI
https://doi.org/10.1007/s00787-009-0081-0
Status
Postprint; peer reviewed
Licence
PEER Licence Agreement (applicable only to documents from PEER project)