dc.contributor.author | Gärtner, Matti | de |
dc.contributor.author | Weigand, Anne | de |
dc.contributor.author | Meiering, Marvin Sören | de |
dc.contributor.author | Weigner, David | de |
dc.contributor.author | Carstens, Luisa | de |
dc.contributor.author | Keicher, Christian | de |
dc.contributor.author | Hertrampf, Rita | de |
dc.contributor.author | Beckmann, Christian | de |
dc.contributor.author | Mennes, Maarten | de |
dc.contributor.author | Wunder, Andreas | de |
dc.contributor.author | Grimm, Simone | de |
dc.date.accessioned | 2025-03-14T09:38:26Z | |
dc.date.available | 2025-03-14T09:38:26Z | |
dc.date.issued | 2023 | de |
dc.identifier.issn | 1740-634X | de |
dc.identifier.uri | https://www.ssoar.info/ssoar/handle/document/100778 | |
dc.description.abstract | There is intriguing evidence suggesting that ketamine might have distinct acute and delayed neurofunctional effects, as its acute administration transiently induces schizophrenia-like symptoms, while antidepressant effects slowly emerge and are most pronounced 24 h after administration. Studies attempting to characterize ketamine’s mechanism of action by using blood oxygen level dependent (BOLD) imaging have yielded inconsistent results regarding implicated brain regions and direction of effects. This may be due to intrinsic properties of the BOLD contrast, while cerebral blood flow (CBF), as measured with arterial spin labeling, is a single physiological marker more directly related to neural activity. As effects of acute ketamine challenge are sensitive to modulation by pretreatment with lamotrigine, which inhibits glutamate release, a combination of these approaches should be particularly suited to offer novel insights. In total, 75 healthy participants were investigated in a double blind, placebo-controlled, randomized, parallel-group study and underwent two scanning sessions (acute/post 24 h.). Acute ketamine administration was associated with higher perfusion in interior frontal gyrus (IFG) and dorsolateral prefrontal cortex (DLPFC), but no other investigated brain region. Inhibition of glutamate release by pretreatment with lamotrigine abolished ketamine’s effect on perfusion. At the delayed time point, pretreatment with lamotrigine was associated with lower perfusion in IFG. These findings underscore the idea that regionally selective patterns of CBF changes reflect proximate effects of modulated glutamate release on neuronal activity. Furthermore, region- specific sustained effects indicate both a swift restoration of disturbed homeostasis in DLPFC as well changes occurring beyond the immediate effects on glutamate signaling in IFG. | de |
dc.language | en | de |
dc.subject.ddc | Psychologie | de |
dc.subject.ddc | Psychology | en |
dc.subject.other | Deutsche Version der Positive and Negative Affect Schedule PANAS (GESIS Panel) (ZIS 242) | de |
dc.title | Region- and time- specific effects of ketamine on cerebral blood flow: a randomized controlled trial | de |
dc.description.review | begutachtet (peer reviewed) | de |
dc.description.review | peer reviewed | en |
dc.source.journal | Neuropsychopharmacology | |
dc.source.volume | 48 | de |
dc.publisher.country | GBR | de |
dc.source.issue | 12 | de |
dc.subject.classoz | psychische Störungen, Behandlung und Prävention | de |
dc.subject.classoz | Psychological Disorders, Mental Health Treatment and Prevention | en |
dc.subject.thesoz | psychische Gesundheit | de |
dc.subject.thesoz | mental health | en |
dc.subject.thesoz | neuropsychologie | de |
dc.subject.thesoz | neuropsychology | en |
dc.subject.thesoz | Droge | de |
dc.subject.thesoz | drug | en |
dc.subject.thesoz | Schizophrenie | de |
dc.subject.thesoz | schizophrenia | en |
dc.subject.thesoz | psychische Störung | de |
dc.subject.thesoz | mental disorder | en |
dc.subject.thesoz | psychische Krankheit | de |
dc.subject.thesoz | mental illness | en |
dc.identifier.urn | urn:nbn:de:0168-ssoar-100778-9 | |
dc.rights.licence | Creative Commons - Namensnennung 4.0 | de |
dc.rights.licence | Creative Commons - Attribution 4.0 | en |
ssoar.contributor.institution | FDB | de |
internal.status | formal und inhaltlich fertig erschlossen | de |
internal.identifier.thesoz | 10055619 | |
internal.identifier.thesoz | 10071064 | |
internal.identifier.thesoz | 10041262 | |
internal.identifier.thesoz | 10057246 | |
internal.identifier.thesoz | 10054529 | |
internal.identifier.thesoz | 10044781 | |
dc.type.stock | article | de |
dc.type.document | Zeitschriftenartikel | de |
dc.type.document | journal article | en |
dc.source.pageinfo | 1735-1741 | de |
internal.identifier.classoz | 10708 | |
internal.identifier.journal | 3313 | |
internal.identifier.document | 32 | |
internal.identifier.ddc | 150 | |
dc.identifier.doi | https://doi.org/10.1038/s41386-023-01605-4 | de |
dc.description.pubstatus | Veröffentlichungsversion | de |
dc.description.pubstatus | Published Version | en |
internal.identifier.licence | 16 | |
internal.identifier.pubstatus | 1 | |
internal.identifier.review | 1 | |
internal.pdf.valid | false | |
internal.pdf.wellformed | true | |
internal.pdf.encrypted | false | |