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[journal article]

dc.contributor.authorGärtner, Mattide
dc.contributor.authorWeigand, Annede
dc.contributor.authorMeiering, Marvin Sörende
dc.contributor.authorWeigner, Davidde
dc.contributor.authorCarstens, Luisade
dc.contributor.authorKeicher, Christiande
dc.contributor.authorHertrampf, Ritade
dc.contributor.authorBeckmann, Christiande
dc.contributor.authorMennes, Maartende
dc.contributor.authorWunder, Andreasde
dc.contributor.authorGrimm, Simonede
dc.date.accessioned2025-03-14T09:38:26Z
dc.date.available2025-03-14T09:38:26Z
dc.date.issued2023de
dc.identifier.issn1740-634Xde
dc.identifier.urihttps://www.ssoar.info/ssoar/handle/document/100778
dc.description.abstractThere is intriguing evidence suggesting that ketamine might have distinct acute and delayed neurofunctional effects, as its acute administration transiently induces schizophrenia-like symptoms, while antidepressant effects slowly emerge and are most pronounced 24 h after administration. Studies attempting to characterize ketamine’s mechanism of action by using blood oxygen level dependent (BOLD) imaging have yielded inconsistent results regarding implicated brain regions and direction of effects. This may be due to intrinsic properties of the BOLD contrast, while cerebral blood flow (CBF), as measured with arterial spin labeling, is a single physiological marker more directly related to neural activity. As effects of acute ketamine challenge are sensitive to modulation by pretreatment with lamotrigine, which inhibits glutamate release, a combination of these approaches should be particularly suited to offer novel insights. In total, 75 healthy participants were investigated in a double blind, placebo-controlled, randomized, parallel-group study and underwent two scanning sessions (acute/post 24 h.). Acute ketamine administration was associated with higher perfusion in interior frontal gyrus (IFG) and dorsolateral prefrontal cortex (DLPFC), but no other investigated brain region. Inhibition of glutamate release by pretreatment with lamotrigine abolished ketamine’s effect on perfusion. At the delayed time point, pretreatment with lamotrigine was associated with lower perfusion in IFG. These findings underscore the idea that regionally selective patterns of CBF changes reflect proximate effects of modulated glutamate release on neuronal activity. Furthermore, region- specific sustained effects indicate both a swift restoration of disturbed homeostasis in DLPFC as well changes occurring beyond the immediate effects on glutamate signaling in IFG.de
dc.languageende
dc.subject.ddcPsychologiede
dc.subject.ddcPsychologyen
dc.subject.otherDeutsche Version der Positive and Negative Affect Schedule PANAS (GESIS Panel) (ZIS 242)de
dc.titleRegion- and time- specific effects of ketamine on cerebral blood flow: a randomized controlled trialde
dc.description.reviewbegutachtet (peer reviewed)de
dc.description.reviewpeer revieweden
dc.source.journalNeuropsychopharmacology
dc.source.volume48de
dc.publisher.countryGBRde
dc.source.issue12de
dc.subject.classozpsychische Störungen, Behandlung und Präventionde
dc.subject.classozPsychological Disorders, Mental Health Treatment and Preventionen
dc.subject.thesozpsychische Gesundheitde
dc.subject.thesozmental healthen
dc.subject.thesozneuropsychologiede
dc.subject.thesozneuropsychologyen
dc.subject.thesozDrogede
dc.subject.thesozdrugen
dc.subject.thesozSchizophreniede
dc.subject.thesozschizophreniaen
dc.subject.thesozpsychische Störungde
dc.subject.thesozmental disorderen
dc.subject.thesozpsychische Krankheitde
dc.subject.thesozmental illnessen
dc.identifier.urnurn:nbn:de:0168-ssoar-100778-9
dc.rights.licenceCreative Commons - Namensnennung 4.0de
dc.rights.licenceCreative Commons - Attribution 4.0en
ssoar.contributor.institutionFDBde
internal.statusformal und inhaltlich fertig erschlossende
internal.identifier.thesoz10055619
internal.identifier.thesoz10071064
internal.identifier.thesoz10041262
internal.identifier.thesoz10057246
internal.identifier.thesoz10054529
internal.identifier.thesoz10044781
dc.type.stockarticlede
dc.type.documentZeitschriftenartikelde
dc.type.documentjournal articleen
dc.source.pageinfo1735-1741de
internal.identifier.classoz10708
internal.identifier.journal3313
internal.identifier.document32
internal.identifier.ddc150
dc.identifier.doihttps://doi.org/10.1038/s41386-023-01605-4de
dc.description.pubstatusVeröffentlichungsversionde
dc.description.pubstatusPublished Versionen
internal.identifier.licence16
internal.identifier.pubstatus1
internal.identifier.review1
internal.pdf.validfalse
internal.pdf.wellformedtrue
internal.pdf.encryptedfalse


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