Endnote export
%T Differences in hypothalamic–pituitary–adrenal axis functioning among children with ADHD predominantly inattentive and combined types %A West, Dirk %A Claes, Stephan %A Deboutte, Dirk %J European Child & Adolescent Psychiatry %N 9 %P 543-553 %V 18 %D 2009 %K ADHD; Children; Cortisol; HPA axis %= 2010-11-15T13:48:00Z %~ http://www.peerproject.eu/ %> https://nbn-resolving.org/urn:nbn:de:0168-ssoar-202684 %X Some evidence suggests that the HPA axis may be dysfunctional in children with attention-deficit/ hyperactivity disorder (ADHD). The aim of this study was to investigate whether a different pattern of HPA axis activity is found between the inattentive (I) and combined (C) subtypes of ADHD, in comparison with healthy control children. A total of 100 prepubertal subjects [52 children with ADHD combined type (ADHD-C), 23 children with ADHD predominantly inattentive type (ADHD-I), and 25 healthy control subjects] were studied. The effects of stress were studied by comparing cortisol responses to a psychosocial stressor, consisting of a public speaking task. Children with ADHD-I showed an elevated cortisol response to the psychosocial stressor, in contrast to children with ADHD-C who showed a blunted cortisol response to the psychosocial stressor. When a distinction was made between responders and non-responders (a subject was classified as a responder when there was an increase in cortisol reactivity), hyperactivity symptoms were clearly related to a lower cortisol reactivity to stress. The results indicate that a low-cortisol responsivity to stress may be a neurobiological marker for children with ADHD-C, but not for those with ADHD-I. Directions for future research and clinical implications are discussed. %C DEU %G en %9 journal article %W GESIS - http://www.gesis.org %~ SSOAR - http://www.ssoar.info