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@article{ Jagodzinski2020,
 title = {Rationale and Design of the Hamburg City Health Study},
 author = {Jagodzinski, Annika and Johansen, Christoffer and Koch‑Gromus, Uwe and Aarabi, Ghazal and Adam, Gerhard and Anders, Sven and Augustin, Matthias and der Kellen, Ramona B. and Beikler, Thomas and Behrendt, Christian-Alexander and Betz, Christian S. and Bokemeyer, Carsten and Borof, Katrin and Briken, Peer and Busch, Chia-Jung and Büchel, Christian and Brassen, Stefanie and Debus, Eike S. and Eggers, Larissa and Fiehler, Jens and Gallinat, Jürgen and Gellißen, Simone and Gerloff, Christian and Girdauskas, Evaldas and Gosau, Martin and Graefen, Markus and Härter, Martin and Harth, Volker and Heidemann, Christoph and Heydecke, Guido and Huber, Tobias B. and Hussein, Yassin and Kampf, Marvin O. and Knesebeck, Olaf von dem and Konnopka, Alexander and König, Hans-Helmut and Kromer, Robert and Kubisch, Christian and Kühn, Simone and Loges, Sonja and Löwe, Bernd and Lund, Gunnar and Meyer, Christian and Nagel, Lina and Nienhaus, Albert and Pantel, Klaus and Petersen, Elina and Püschel, Klaus and Reichenspurner, Hermann and Sauter, Guido and Scherer, Martin and Scherschel, Katharina and Schiffner, Ulrich and Schnabel, Renate B. and Schulz, Holger and Smeets, Ralf and Sokalskis, Vladislavs and Spitzer, Martin S. and Terschüren, Claudia and Thederan, Imke and Thoma, Tom and Thomalla, Götz and Waschki, Benjamin and Wegscheider, Karl and Wenzel, Jan-Per and Wiese, Susanne and Zyriax, Birgit-Christiane and Zeller, Tanja and Blankenberg, Stefan},
 journal = {European Journal of Epidemiology},
 number = {2},
 pages = {169-181},
 volume = {35},
 year = {2020},
 issn = {1573-7284},
 doi = {https://doi.org/10.1007/s10654-019-00577-4},
 urn = {https://nbn-resolving.org/urn:nbn:de:0168-ssoar-74896-8},
 abstract = {The Hamburg City Health Study (HCHS) is a large, prospective, long-term, population-based cohort study and a unique research platform and network to obtain substantial knowledge about several important risk and prognostic factors in major chronic diseases. A random sample of 45,000 participants between 45 and 74 years of age from the general population of Hamburg, Germany, are taking part in an extensive baseline assessment at one dedicated study center. Participants undergo 13 validated and 5 novel examinations primarily targeting major organ system function and structures including extensive imaging examinations. The protocol includes validate self-reports via questionnaires regarding lifestyle and environmental conditions, dietary habits, physical condition and activity, sexual dysfunction, professional life, psychosocial context and burden, quality of life, digital media use, occupational, medical and family history as well as healthcare utilization. The assessment is completed by genomic and proteomic characterization. Beyond the identification of classical risk factors for major chronic diseases and survivorship, the core intention is to gather valid prevalence and incidence, and to develop complex models predicting health outcomes based on a multitude of examination data, imaging, biomarker, psychosocial and behavioral assessments. Participants at risk for coronary artery disease, atrial fibrillation, heart failure, stroke and dementia are invited for a visit to conduct an additional MRI examination of either heart or brain. Endpoint assessment of the overall sample will be completed through repeated follow-up examinations and surveys as well as related individual routine data from involved health and pension insurances. The study is targeting the complex relationship between biologic and psychosocial risk and resilience factors, chronic disease, health care use, survivorship and health as well as favorable and bad prognosis within a unique, large-scale long-term assessment with the perspective of further examinations after 6 years in a representative European metropolitan population.},
 keywords = {nutrition; prognosis; Bundesrepublik Deutschland; Gesundheit; heart disease; adipositas; Hamburg; Public Health; risk; prophylaxis; cancer; chronic illness; Federal Republic of Germany; Lebensstil; Hamburg; stroke; epidemiology; mental illness; dementia; resilience; Gesundheitsvorsorge; chronische Krankheit; longitudinal study; Herzkrankheit; public health; Längsschnittuntersuchung; life style; Demenz; Risiko; Resilienz; health care; Prognose; Gesundheitsversorgung; Fettsucht; Schlaganfall; Prophylaxe; Ernährung; Epidemiologie; Krebs; psychische Krankheit; health}}