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Expression analyses of the mitochondrial complex I 75-kDa subunit in early onset schizophrenia and autism spectrum disorder: increased levels as a potential biomarker for early onset schizophrenia

[journal article]

Taurines, Regina; Thome, Johannes; Duvigneau, J. Catharina; Forbes-Robertson, Sarah; Yang, Liya; Klampfl, Karin; Romanos, Jasmin; Müller, Sabine; Gerlach, Manfred; Mehler-Wex, Claudia

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Abstract Searching for a peripheral biological marker for schizophrenia, we previously reported on elevated mitochondrial complex I 75-kDa subunit mRNA-blood concentrations in early onset schizophrenia (EOS). The aim of this study was to further evaluate the utility of this gene as a potential marker for schizophrenia. Both—schizophrenia and autism—are suggested to be neuronal maldevelopmental disorders with reports of mitochondrial dysfunction and increased oxidative stress. Therefore we have investigated the expression levels of mitochondrial complex I 75-kDa subunit mRNA in whole blood of children with autistic spectrum disorder (ASD) and a group of adolescent acute first-episode EOS patients in comparison to matched controls. We have found that compared to the respective controls only the group of EOS patients—and not the ASD group—showed a significantly altered expression of the complex I 75-kDa subunit mRNA. Although further studies are necessary to test for the specificity of this marker, our findings point to the potential use of the mitochondrial complex I as a biomarker for schizophrenia.
Classification Psychological Disorders, Mental Health Treatment and Prevention
Free Keywords Biological marker; Mitochondrial complex I; 75-kDa subunit; Early onset schizophrenia; Autistic spectrum disorder
Document language English
Publication Year 2009
Page/Pages p. 441-448
Journal European Child & Adolescent Psychiatry, 19 (2009) 5
DOI http://dx.doi.org/10.1007/s00787-009-0074-z
Status Postprint; peer reviewed
Licence PEER Licence Agreement (applicable only to documents from PEER project)