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Outcomes of medical management of peripheral arterial disease in general practice: follow-up results of the PACE-PAD Study

[journal article]

Neumann, Anja; Jahn, Rebecca; Diehm, Curt; Driller, Elke; Hessel, Franz; Lux, Gerald; Ommen, Oliver; Pfaff, Holger; Siebert, Uwe; Pittrow, David; Wasem, Jürgen

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Abstract Aim: Peripheral arterial disease (PAD), a marker of elevated vascular risk, is highly prevalent in general practice. We aimed to investigate patient characteristics and outcomes of PAD patients treated according to the guidelines versus those who were not. Methods: The Patient Care Evaluation-Peripheral Arterial Disease Study (PACE-PAD) was a multicenter, cluster randomized, prospective, longitudinal cohort study of patients with PAD in primary care, who were followed up for death or vascular events over 18 months. Guideline orientation was assumed if patients received anticoagulant/antiplatelet therapy, exercise training, and (if applicable) advice for smoking cessation and therapy of diabetes mellitus, hypertension, or hypercholesterolemia, respectively. Results: Of the 5,099 PAD patients (mean age 68.0 ± 9.0 years, 68.5% male subjects) who were followed up, 22.5, 34.6, 30.1, 7.8, and 3.5% (1.5% not specified) were in Fontaine stages I, IIa, IIb, III, and IV. Comprehensive guideline orientation was reported in 28.4% only; however, patients in lower Fontaine stages received guideline-oriented therapy more often (I: 30.3%, IIa: 31.6%, IIb: 29.1%, III: 9.8%, IV: 18.0%). During 18 months, 457 patients died (224 due to cerebrovascular or coronary deaths), 319 had unstable angina pectoris, 116 myocardial infarction, and 140 an ischemic stroke event. In total, 24% of patients had experienced any vascular event (19.1% a first event). Event rates did not differ between patients treated according to guidelines and those who were not. Conclusion: The present PAD cohort was a high-risk sample with an unexpectedly high rate of deaths and vascular events. While physicians appear to focus on the treatment of individual risk factors, rates of comprehensive PAD management in line with guideline recommendations are still suboptimal. Factors contributing to the lacking difference between outcomes in the guideline-oriented and non-guideline-oriented groups may comprise low treatment intensity or other reasons for unsatisfactory effect of treatment, misclassification of events, and patient’s noncompliance with therapy.
Classification Medicine, Social Medicine
Free Keywords Guideline orientation; Peripheral arterial disease; Outcomes; Intermittent claudication; Observational study
Document language English
Publication Year 2010
Page/Pages p. 523-532
Journal Journal of Public Health, 18 (2010) 6
DOI http://dx.doi.org/10.1007/s10389-010-0356-4
Status Postprint; peer reviewed
Licence PEER Licence Agreement (applicable only to documents from PEER project)