Genetics of autistic disorders: review and clinical implications

Freitag, Christine M.; Staal, Wouter; Klauck, Sabine M.; Duketis, Eftichia; Waltes, Regina

[journal article]

dc.contributor.author	Freitag, Christine M.	de
dc.contributor.author	Staal, Wouter	de
dc.contributor.author	Klauck, Sabine M.	de
dc.contributor.author	Duketis, Eftichia	de
dc.contributor.author	Waltes, Regina	de
dc.date.accessioned	2010-11-26T02:51:00Z	de
dc.date.accessioned	2012-08-29T23:04:23Z
dc.date.available	2012-08-29T23:04:23Z
dc.date.issued	2009	de
dc.identifier.uri	http://www.ssoar.info/ssoar/handle/document/20726
dc.description.abstract	Twin and family studies in autistic disorders (AD) have elucidated a high heritability of AD. In this literature review, we will present an overview on molecular genetic studies in AD and highlight the most recent findings of an increased rate of copy number variations in AD. An extensive literature search in the PubMed database was performed to obtain English published articles on genetic findings in autism. Results of linkage, (genome wide) association and cytogenetic studies are presented, and putative aetiopathological pathways are discussed. Implications of the different genetic findings for genetic counselling and genetic testing at present will be described. The article ends with a prospectus on future directions.	en
dc.language	en	de
dc.subject.ddc	Psychology	en
dc.subject.ddc	Medicine and health	en
dc.subject.ddc	Medizin und Gesundheit	de
dc.subject.ddc	Psychologie	de
dc.subject.other	Autistic disorder; Linkage; Whole genome association; Copy number variation; Mutation
dc.title	Genetics of autistic disorders: review and clinical implications	en
dc.description.review	begutachtet (peer reviewed)	de
dc.description.review	peer reviewed	en
dc.source.journal	European Child & Adolescent Psychiatry	de
dc.source.volume	19	de
dc.publisher.country	DEU
dc.source.issue	3	de
dc.subject.classoz	Medizin, Sozialmedizin	de
dc.subject.classoz	Psychological Disorders, Mental Health Treatment and Prevention	en
dc.subject.classoz	Medicine, Social Medicine	en
dc.subject.classoz	psychische Störungen, Behandlung und Prävention	de
dc.identifier.urn	urn:nbn:de:0168-ssoar-207269	de
dc.date.modified	2010-11-26T09:45:00Z	de
dc.rights.licence	PEER Licence Agreement (applicable only to documents from PEER project)	de
dc.rights.licence	PEER Licence Agreement (applicable only to documents from PEER project)	en
ssoar.gesis.collection	SOLIS;ADIS	de
ssoar.contributor.institution	http://www.peerproject.eu/	de
internal.status	3	de
dc.type.stock	article	de
dc.type.document	journal article	en
dc.type.document	Zeitschriftenartikel	de
dc.rights.copyright	f	de
dc.source.pageinfo	169-178
internal.identifier.classoz	50100
internal.identifier.classoz	10708
internal.identifier.journal	111	de
internal.identifier.document	32
internal.identifier.ddc	610
internal.identifier.ddc	150
dc.identifier.doi	https://doi.org/10.1007/s00787-009-0076-x	de
dc.description.pubstatus	Postprint	en
dc.description.pubstatus	Postprint	de
internal.identifier.licence	7
internal.identifier.pubstatus	2
internal.identifier.review	1
internal.check.abstractlanguageharmonizer	CERTAIN
internal.check.languageharmonizer	CERTAIN_RETAINED

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psychische Störungen, Behandlung und Prävention
Psychological Disorders, Mental Health Treatment and Prevention
Medizin, Sozialmedizin
Medicine, Social Medicine

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