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%T Does HPA-axis activity mediate the relationship between obstetric complications and externalizing behavior problems? The TRAILS study %A Marsman, Rianne %A Rosmalen, Judith G. M. %A Oldehinkel, Albertine J. %A Ormel, Johan %A Buitelaar, Jan K. %J European Child & Adolescent Psychiatry %N 9 %P 565-573 %V 18 %D 2009 %K Early adolescence; Externalizing behavior problems; Cortisol; Pre- and perinatal risk factors; General population %= 2010-11-16T10:00:00Z %~ http://www.peerproject.eu/ %> https://nbn-resolving.org/urn:nbn:de:0168-ssoar-202712 %X To examine whether HPA-axis activity mediates the relationship between obstetric complications (OCs) and externalizing behavior problems, and to investigate whether this model is different for boys and girls. In a population-based cohort of 1,768 10- to 12-year-old early adolescents, we assessed the cortisol awakening response and evening cortisol levels. Externalizing behavior problems were assessed using the Child Behavior Checklist and the Youth Self-Report. OCs were retrospectively assessed in a parent interview. OCs significantly predicted externalizing behavior problems, but OCs did not predict HPA-axis activity. Thus, the mediation model was not supported. In addition to the relationship between HPA-axis activity and externalizing behavior problems, which is specific for girls, there is also a relationship between OCs and externalizing behavior problems. However, these two mechanisms are not related to each other indicating that HPA-axis activity is not a mediator in the relationship between OCs and externalizing behavior problems. Future research should focus on understanding the mechanism through which OCs cause externalizing behavior problems. %C DEU %G en %9 journal article %W GESIS - http://www.gesis.org %~ SSOAR - http://www.ssoar.info