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Obstetric complications as a risk factor for first psychotic episodes in childhood and adolescence

[journal article]

Moreno, Dolores; Moreno-Iñiguez, Miguel; Vigil, Dolores; Castro-Fornieles, Josefina; Ortuño, Felipe; González-Pinto, Ana; Parellada, Mara; Baeza, Inmaculada; Otero, Soraya; Graell, Montserrat; Aldama, Ana; Arango, Celso

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Abstract There are reports of significant association between obstetric complications (OC) and childhood psychosis. Authors conducted a case-control study of 102 children and adolescents with a first episode psychosis (FEP) and 94 healthy controls (HC), using the obstetric complications scale (OCS) and their medical records, to examine the risk of FPE. Patients were recruited from child and adolescent psychiatry units at six university hospitals and controls from publicly-funded schools of similar characteristics and from the same geographic areas. A logistic regression was performed to quantify the risk of psychosis in childhood and adolescence, based on OC, adjusting for potential confounding factors like socio economic status (SES) and family psychiatric history (FPH). OC appeared more frequently in the records of patients. Significant differences between patients and controls were found in Prenatal OC (15.7% vs. 5.3%, P < 0.05) and among them, bleeding in pregnancy showed the greatest difference between groups (12.7% vs. 2.1%, P < 0.01). In the logistic regression, bleeding in pregnancy showed a crude odds ratio (OR) of 6.7 (95%CI = 1.4–30.6) and 5.1 (CI 95% = 1.0–24.9) adjusted for SES and FPH. Therefore, bleeding in pregnancy is a likely risk factor for early-onset psychosis.
Classification Psychological Disorders, Mental Health Treatment and Prevention; Medicine, Social Medicine
Free Keywords early psychosis; first onset; case-control; OCS
Document language English
Publication Year 2009
Page/Pages p. 180-184
Journal European Child & Adolescent Psychiatry, 18 (2009) 3
DOI http://dx.doi.org/10.1007/s00787-008-0692-x
Status Postprint; peer reviewed
Licence PEER Licence Agreement (applicable only to documents from PEER project)