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Olanzapine compared to quetiapine in adolescents with a first psychotic episode

[journal article]

Arango, Celso; Robles, Olalla; Parellada, Mara; Fraguas, David; Ruiz-Sancho, Ana; Medina, Oscar; Zabala, Arantzazu; Bombín, Igor; Moreno, Dolores

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Please use the following Persistent Identifier (PID) to cite this document:http://nbn-resolving.de/urn:nbn:de:0168-ssoar-123053

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Abstract Objective: To compare the efficacy, safety, and tolerability of olanzapine and quetiapine in adolescents with first episode psychosis. Method: Fifty adolescents (age 16 ± 1.25) with a first episode of psychosis were randomized to quetiapine or olanzapine in a 6-month open label study. Efficacy and side effect scales, as well as vital signs and laboratory data were recorded at baseline, 7, 15, 30, 90, and 180 days (end of study). Results: Out of the total sample included in the study, 32 patients completed the trial (quetiapine n = 16, olanzapine n = 16). Patients in both treatment groups had a significant reduction in all clinical scales with the exception of the negative scale of the Positive and Negative Symptom Scale (PANSS) for olanzapine and the general psychopathology scale of the PANSS for quetiapine. The only difference between treatment arms on the clinical scales was observed on the patients' strength and difficulties questionnaire (SDQ) scale, with greater improvement for olanzapine. Patients on olanzapine gained 15.5 kg and patients on quetiapine gained 5.5 kg. Conclusion: Olanzapine and quetiapine reduced psychotic symptoms in this adolescent sample. Patients on olanzapine gained significantly more weight. Side effects with both drugs seemed to be more prevalent than those reported in adult studies.
Classification Psychological Disorders, Mental Health Treatment and Prevention
Free Keywords olanzapine; quetiapine; safety; tolerability; adolescent; first episode psychosis;
Document language English
Publication Year 2009
Page/Pages p. 418-428
Journal European Child & Adolescent Psychiatry, 18 (2009) 7
DOI http://dx.doi.org/10.1007/s00787-009-0749-5
Status Published Version; peer reviewed
Licence PEER Licence Agreement (applicable only to documents from PEER project)