Weiterempfehlen

Bookmark and Share


Executive dysfunction in treated phenylketonuric patients

[Zeitschriftenartikel]

Azadi, Bahare; Seddigh, Arshia; Tehrani-Doost, Mehdi; Alaghband-Rad, Javad; Ashrafi, Mahmoud Reza

Zitationshinweis

Bitte beziehen Sie sich beim Zitieren dieses Dokumentes immer auf folgenden Persistent Identifier (PID):http://nbn-resolving.de/urn:nbn:de:0168-ssoar-122830

Weitere Angaben:
Abstract Objectives: Executive function deficits have been described in early and continuously treated patients with phenylketonuria (PKU). The aim of this study was to examine performance on executive function tasks of treated patients with PKU diagnosed by 2 years of age. Patients and methods: Ten patients with PKU and normal intelligence score who were diagnosed before the age of 2 years and subsequently treated continuously, were compared with 15 typically developing control children on a battery of neuropsychological tests, including the tower of London (TOL), continuous performance test (CPT), and Stroop test. Results: PKU cases showed significantly poorer performance on the TOL task compared to the control group with the difference being significant in the first three levels of the test. With the CPT, PKU cases had significantly more omission errors than control subjects. On the Stroop test there was no statistically significant difference between the groups. No significant correlation was found between the concurrent serum phenylalanine (Phe) level and results of the executive tests in PKU patients. Conclusion: This study identified executive dysfunction in early-treated PKU patients with normal IQ, particularly in the planning and attention domains. Further studies are required to compare the results with those from other neurodevelopmental disorders such as ADHD and autism, to establish whether the pattern of findings is specific to PKU.
Klassifikation psychische Störungen, Behandlung und Prävention; Medizin, Sozialmedizin
Freie Schlagwörter early-treated phenylketonuria; executive function; neuropsychology; serum phenylalanine;
Sprache Dokument Englisch
Publikationsjahr 2009
Seitenangabe S. 360-368
Zeitschriftentitel European Child & Adolescent Psychiatry, 18 (2009) 6
DOI http://dx.doi.org/10.1007/s00787-009-0738-8
Status Veröffentlichungsversion; begutachtet (peer reviewed)
Lizenz PEER Licence Agreement (applicable only to documents from PEER project)
top